Don’t get surprised or annoyed when you hear “erections start in the brain!” Making love is a sheer chemical process. Do you doubt? Let Smart Canadian Pharmacy clarify you a little something, my friend.
When you see, feel, smell, hear, or try to remember something, your hypothalamus (a small area in the brain responsible for a good deal of functions, including the CNS activity) triggers your nerves system to generate electrical signals: sexual arousal has come! It’s time to act!
Having received the command of their “chief”, the parasympathetic nervous system starts conducting electrical impulses from the brain down the spinal cord. Then your spinal cord nerves transmit the signal to their “colleagues” in the pelvic area. Pelvic nerves command the blood vessels to relax and let the blood flow in. Once the blood fills the phallus, the cavernous bodies are commanded to trap blood inside your male organ. The penis gets swollen and rigid. Sexual performances become possible.
If a penis is naturally stimulated, this provokes an erection, doesn’t it? In this case, the pudendal nerve will carry a sexual sensation. This nerve runs from a shaft to a sacral nerve, located in a lower spine. These sacral nerves send impulses to the penile arteries to widen, relax, and let blood through. Hence, pudendal and sacral nerve pathways are involved into erection producing. This is how an erection is described from the physical point of view. But there is also an active participation of some chemicals.
The chemistry of erections
How do nerves transmit signals? They release nitric oxide and pass it to each other. This nitric oxide acts as a chemical messenger: traveling from a nerve to nerve, it boosts production of other chemicals important for a penile rigidness (prostaglandin, vasoactive intestinal polypeptide, and cGMP cyclic guanosine monophosphate). Penile arteries are covered with smooth muscle cells and lead to the cavernous bodies (a pair of hollow cylinders running along the whole length of a penis). The trio of our chemicals relaxes the muscle cells inside a penis so that arteries can admit blood.
A male organ consists of three cylindrical parts: the spongy body (includes a urethra and penile glans) and two cavernous bodies (also known as erectile bodies or corpora cavernosa). The cavernous bodies are penis-long to support a full erection.
When the vessels are commanded to relax, the millions of caverns (tiny holes inside the corpora cavernosa) get filled with blood. During an erection, the blood flow within a penis is 6 times stronger compared to the normal state. Soon after the corpora cavernosa are filled with blood, the veins’ openings close to prevent premature blood drainage. Blood trapped inside the penis is the simplest explanation for the mechanics of erectile function.
There are signals that bring an erection to end (an orgasm, interruption, distraction). Detumescence (the scientific term describing an end of erection) occurs as a result of that the chemical messenger (nitric oxide) is not produced by the nerves. There is an enzyme (PDE5 –phosphodiesterase 5) that is aimed to destroy chemical messengers after a sexual intercourse. This enzyme makes blood seep out of the caverns inside the cavernous bodies so that the arteries open up and blood passes away. Consequently, a phallus gets flaccid again.
The mechanics of Erectile Dysfunction
ED is described as a condition at which a man cannot obtain or/and maintain a firm erection for a full-fledged sexual activity. Since an erection is a result of neurovascular activity, any disease or trauma that affects the brain, spinal cord, pudendal nerves or cavernous nerves of a penis and can give rise to erectile dysfunction. There are three main causes of erectile dysfunction:
- Failure to initiate erection (neurogenic case);
- Failure to fill blood vessels (cardiovascular case);
- Failure to trap blood (venous case).
Hence, erectile frustration can have a psychological and physical nature. Our online platform will provide you with exhausted information on these causes of ED.
Causes of psychological Erectile Dysfunction
Depression and concomitant mood disorders (anxiety, stress, mental problems) induce sexual dysfunction. During stress, a middle area of the adrenal cortex starts producing a hormone cortisol. An excess of cortisol overwhelms the hypothalamus and hippocampus causing their atrophy.
During a depression, there is a deficiency of serotonin – the neurotransmitter found in the brain. The insufficient serotonin results in a low mood, feeling of low self-esteem, insomnia, panic attacks, obesity, and even asthma. Without this neurotransmitter, the neurons cannot transmit electrical impulses well and stop communicating with each other. If nerves do not transmit signals of the brain, an erection will not come.
Causes of physical Erectile Dysfunction
As you already know, the hypothalamus located in the cerebral cortex, controls sexual behavior, sexual drive, and erection. There are conditions such as a stroke, Parkinson’s disease, tumors, epilepsy, and cephalitis induce pathologic processes in the hippocampus and paraventricular nucleus (parts of the hypothalamus). When hypothalamus is damaged, it cannot generate and transmit impulses to the pelvic nerves.
Spinal cord injuries and pelvic fractures may impair an erectile function as well. If a spinal cord is damaged, the sacral parasympathetic nerves start malfunctioning and their synaptic connections become disable to release nitric oxide properly.
Such surgery on the pelvic organs as radical prostatectomy or perineal prostatectomy for benign neoplasm may affect the cavernous nerves, which facilitate erection.
An erectile impairment may occur in a case of vitamin deficiency, alcoholism or diabetes. During numerous tests and researches, Smart Canadian Pharmacy has established that these conditions have a negative impact on the cavernous nerve terminals what results in an inadequate release of neurotransmitters (nitric oxide, prostaglandin, vasoactive intestinal polypeptide, and cGMP cyclic).
Atherosclerosis, veno-occlusive dysfunction, and trauma of arteries diminish the perfusion pressure, damage the smooth muscle relaxation and decrease the blood flow to the penile tissues what influences the rigidity of a male organ.
Antidepressants consumption may also affect the male sexual power. SSRIs interfere with the brain chemistry causing the neurons to work and communicate inadequately.
What is the use of PDE5 inhibitors?
The penile erection occurs under sexual stimulation when there is a release of nitric oxide (NO) from the neurons’ synapses. NO invokes widening of the blood vessels inside the cavernous body through the collection of cGMP – cyclic guanosine monophosphate that makes smooth muscle relax facilitating a firm erection. Phosphodiesterase Type 5 or PDE5, an enzyme found in the corpus cavernosum, suppresses the cGMP and breaks down the vasodilatory effect of nitric oxide. This process happens when the brain commands to stop an erection (an orgasm is a typical signal for this, you know).
Consequently, if PDE5 can be inhibited (blocked, suppressed), an erection can be considerably prolonged. Is there any drug that can inhibit Phosphodiesterase Type 5? Yes, there are at least two effective medications intended for the PDE5 inhibition!
Generic Viagra and Generic Cialis to break your fall
Generic Viagra (Sildenafil) and generic Cialis (Tadalafil) are developed to prevent a breakdown of cGMP by inhibiting PDE5. Also known as PDE5 inhibitors, generic Viagra and Cialis enhance and prolong erection.
Sildenafil (Viagra) and Tadalafil (Cialis) have a molecular structure similar to cGMP. Both these inhibitors are immediately absorbed from the digestive tract with the peak plasma concentrations reached within an hour. That is why the ED medications have a quick action.
Fatty food is known to delay the action of brand Viagra and Cialis but it is not the same for generics. High-fat food has no delaying effect on the absorption extent and rate of Tadalafil and Sildenafil so these drugs may be taken with no regard to a meal.
The pharmacokinetic properties of the two PDE5 inhibitors are not influenced by alcohol intake, although the healthcare providers recommend men to refrain from alcohol, as the alcohol abuse has been proven to be associated with the erectile dysfunction.
The half-life of Viagra is 4 hours, while the half-life of Cialis is about 18 hours. This fact means that the agents must not be taken more than once a day. Such a long action of generic Cialis and Viagra allow ED sufferers more freedom to choose when to engage in sexual performance. The current PDE5 inhibitors leave the body via the hepatic metabolism.
Original Viagra and Cialis have an onset of action in 30-60 minutes while the generics of Viagra and Cialis start acting in 14-20 minutes depending upon an individual response of a patient. Notably, these medications have a pharmacological action when the synthesis of cGMP is started. That is why the sexual arousal is essential for the action of current PDE5 inhibitors.
Generic Viagra and Cialis available in Smart Canadian Pharmacy www.smartcanadianpharmacy.com have a short list of contraindications rather than original drugs:
- history of myocardial infarction or stroke within the last 3 months;
- Abnormal blood pressure (hypo- or hypertension);
- severe cardiac failure or liver impairment;
- unstable angina;
- severe kidney impairment.
The dose of Sildenafil and Cialis are very individual. Before placing an order for your generic Cialis or Generic Viagra, please consult our online medical specialist and provide us with your case history. This will help us prescribe you the best dose at the great price and offer you a personal bonus.