Sildenafil: How It Works
Sildenafil is a medicine for erectile dysfunction falling into the group of PDE5 inhibitors. It provides steady and fully-realized erection which is enough for sexual intercourse. Sildenafil was synthesized in 1998 and became the first truly effective tableted medication for treatment of such widely-spread disease of our days as ED. For understanding the mechanism of sildenafil effects it is important to describe its bio-chemical characteristics. First of all, we should note the relaxing effect of nitrogen oxide (NO) which is produced in vascular endothelium. Then nitrogen oxide penetrates into smooth tissue where gluconeogenic enzyme is released resulting in sudden increase of cell concentration of cyclic guanosine monophosphate (cGMP). The latter prevents from supplying of calcium ions into cells causing the reduction of vascular tone. So, now there appears PDE. It destroys cGMP and limits vasodilative effect of nitrogen oxide by this.
Nowadays it is stated that the most active agent in this regard is PDE5. Thus, inhibition of its activity enhanced effects of nitrogen oxide. Now it is important to study the development basis of erection. The main condition of its appearance is relaxation of smooth “girdle” of arteries delivering blood to cavernous bodies of penis. Such relaxation releases nitrogen oxide produced by endothelial cells. Sildenafil intensifies the NO effects by taking the natural barriers on the way of blood to balanus. Clinical efficiency of sildenafil was demonstrated in a range of large randomised studies.
Fluoxetine at Struggle with Depressions
Fluoxetine is prescribed for treatment of depressions and compulsion neurosis when a patient constantly experiences fear and angst. The medicine has been actively applied for treatment of depressive disorder since 1980. Its regular use reduces apathy, returns good mood and eliminates insomnia. Some women take this drug to lose weight, because it decreases appetite. But the danger lies in its property to accumulate in organism causing central nervous system disorders.
Fluoxetine is prescribed to treat psychic disorders among which are depressions, compulsion neurosis, and bulimia. It inhibits selectively the serotonin reuptake in brain cells. As a result, the concentration of this substance increases in synapses responsible for neurotransmitters transfer from neuron o neuron. Serotonin effect on post-synaptic receptor branches prolongs without causing the reuptake of dopamine, noradrenaline and other neurotransmitters.
The pharmaceutical action of fluoxetine shows as mood improvement and stimulating effect. The anxiety disappears, appetite reduces. Nevertheless this medication doesn’t take any sedative action.
Duloxetine’s Magic Effects
Duloxetine is used to treat major depressive disorder and generalized form of anxious disorder. It is also prescribed for peripheral diabetic neuropathy (severe pain syndrome). Duloxetine is antidepressant, a serotonin and norepinephrine reuptake inhibitor which has a weak inhibiting effect on dopamine reuptake. Thus, its operating principle lies in increase of noradrenergic and serotonergic neurotransmission in central nervous system.
This is a modern medication the double mechanism of which has proved its efficiency in the treatment of depressions of various severity degrees. Besides its high efficiency this anti-depressant has a considerable action rate. Distinct anti-depressant effect is characterized by steadiness and uniformity of action allowing tracing continuous improvements during the whole period of treatment. Moreover, duloxetine has a strong pain alleviating effect occurring during the first two weeks of drug’s intake. The research study of duloxetine efficiency in treatment of a chronic blind headache has proved that this medicine can manage successfully sensation of pain and increase the pain limit. Among 46 patients suffering from chronic blind headache more than a half had serious improvements. Moreover, by the end of treatment course the average number of days without a headache (during a month) had increased by 60%, whereas the frequency of blind headache attack reduced by 40%.
What are the Main Differences between Malegra DXT and Malegra FXT?
These two medications are applied to treat premature ejaculation and erectile dysfunction. According to various clinical trials they have demonstrated their high efficiency. Besides the fact that these drugs have a lot in common, there are some major differences between them. Let’s examine them.
Malegra FXT and Malegra DXT contain 100mg of active substance, sildenafil. Sildenafil is a drug for erectile dysfunction belonging to the group of PDE5 inhibitors. It provides steady and fully-realized erection which is enough for sexual intercourse via blockage in arteries and blood vessels and increase of blood supply to penis.
The secondary components of Malegra FXT is fluoxetine (40mg) and of Malegra DXT – duloxetine (30mg) accordingly. They influence center of the brain in order to inhibit neurons movement from penis to cerebrum resulting in long-lasting coitus. Due to these additional constituents, sexual intercourse is prolonged by four-five times.
The key difference between Malegra FXT and Malegra DXT lies in their above-mentioned secondary components (fluoxetine and duloxetine). Despite the same operating principle, their effect may vary. Some patients can experience lack of tolerability to each of these constituents such as vertigo, somnolence, gastric indigestion, etc.
Fluoxetine is a serotonin reuptake inhibitor whereas duloxetine is a norepinephrine and serotonin reuptake inhibitor. So, they both can influence serotonin absorption, but duloxetine is able to take effect on norepinephrine brain levels.
Fluoxetine and duloxetine’s side-effects are different. For instance, fluoxetine may be a cause of insomnia, increased fatigability, diaphoresis, appetite loss, angst, feeling sick, etc., whereas duloxetine have the following side-effects: xerostomia, sickliness, uncleared bowels, diarrhea, vertigo, drowsiness, headaches, etc.
It is quite difficult to foresee the possible effects on man’s health of Malegra FXT and Malegra DXT, the occurrence of side-effect and lack of tolerance to some of the constituents. If there is no intolerance to sildenafil, the main issue lies in secondary component then. In order to find the most suitable variant, you may experience one of the medications first. If Malegra DXT has an adverse effect on your health, you may always resort to Malegra FXT and V.V. There is also a slight difference in prices for Malegra DXT and Malegra FXT.
Combined Effects of Sildenafil and FXT / DXT for Major Sex Boost
Malegra DXT’s combination of sildenafil and duloxetine
This is an innovative medication capable to solve several problems at once which are connected with potency by means of combination of active components. Sildenafil is Viagra’s constituent which is considered to be the most popular medication to treat erectile dysfunction for men with different etiology. Duloxetine is an anti-depressant. It inhibits serotonin and norepinephrine reuptake resulting in slowing down of nervous impulses in CNS and blocking premature ejaculation. Duloxetine allows prolonging sexual intercourse and protecting from premature ejaculation. Besides, duloxetine is able to provide you with a perfect mood and self-confidence.
The drug affects in an integrated manner, and this distinguishes Malegra DXT from analogous medicines. It contains 100mg of sildenafil and 30mg of duloxetine. Malegra DXT provides a qualitative erection in case of a sexual attraction to a partner. Then all chemical processes in organism start, smooth muscles of lenis get relaxed, the blood flow to sexual organs is enhanced causing filling of cavernous bodies with blood and providing a reliable natural erection.
Main advantages of Malegra DXT:
- Active substances are selected in ideal proportions in order to enhance maximally each other’s effect;
- Efficient to treat all forms of erectile dysfunction;
- One tablet is able to solve four problems: provides natural potency, prolongs sexual intercourse, eliminates premature ejaculation, gives perfect mood;
- Positive effect is achieved in 30 minutes and lasts 15 hours
All men suffering from erectile dysfunction and premature ejaculation are recommended to take Malegra DXT. From now on you shouldn’t take several medications in order to settle several health issues. If taken into account that this drug consists of two active components, the risk of side-effects and counter-indications to combine with other medications increases. Thus, it is essential to consult your attending doctor before taking this drug.
Malegra FXT’s combination of sildenafil and duloxetine
This is a brand new medication combining simultaneously two one-of-a-kind components capable to treat erectile dysfunction and prolong sexual intercourse. This drug has two main components: sildenafil (100mg) and fluoxetine (40mg). Sildenafil is a strong constituent from the group of PDE5 inhibitors which is able to treat all forms of male sexual health problems by enhancing the blood supply to penis. Fluoxetine falls into the group of anti-depressants, but this is not used to protect you from depression, but to make your sex longer and exclude premature emission of seminal fluid. Therefore, Malegra FXT will allow treating not only one disorder, but three in a row: raise spirits, prevent from PE and ensure good erection.
Key benefits of Malegra FXT:
- Perfect combination of two constituents enhancing the effects of each other;
- This medication is effective for all types of erectile disorders;
- Excludes premature ejaculation;
- Price for Malegra FXT is much lower than for its analogues;
- Fast action rate (25-30 minutes before sexual intercourse) and long-lasting effect for about 10 hours.
It goes without saying that this medicine as well as other medications has its use limitations and counter-indications to other components. Please, сheck with your doctor before use of Malegra FXT, since it consists of two active components which have their own side-effects and counter-indications.
This drug is the newest pharmaceutical development, and you may rest assured in its safety and minimal possibility of side-effects. Malegra FXT is not dedicated for sexual excitement; this is a direct-action medication for natural and qualitative erection and premature ejaculation prevention as well. The drug improves semen characteristics, endocrine profile and central nervous system work; therefore it may cause only slight transient side-effects, such as dyspepsia, headache, and allergic rhinitis.
Malegra FXT / DXT at Canadian Pharmacy: Best Prices Quoted
Malegra FXT and Malegra DXT have insignificant counter-indications and side-effects; therefore, they are prescribed for men at any age group, even at advanced age. Medical experts told that men over 70 years old can lead a fully-realized sexual life without premature ejaculation with Malegra FXT or Malegra DXT. The difference between them lies in composition and dosage. You can always buy them in any quantity at Canadian Pharmacy. Our online pharmacy www.smartcanadianpharmacy.com offers the most reasonable prices and secures your privacy. Just place the order on our page, and the product will be delivered to you within the shortest possible time.