Nolvadex is currently widely used in the world for the treatment of breast cancer. This drug is used to prevent the formation of female hormones in the body.
Hormone therapy for cancer has made significant progress over the half-century history of development. After the introduction of non-steroidal antiestrogen into clinical practice the most famous of which is tamoxifen, there has been progress in the treatment of breast cancer. Tamoxifen is an active component of Nolvadex, and it is proved to be one of the best medications in the cancer treatment. Nolvadex medication is considered to be the “gold standard” in the treatment of women with this pathology. It is manufactured by AstraZeneca and its price is pretty available.
Nolvadex dosage and prices in Canada
The necessary dosage is always prescribed only by doctor. But, usually, the drug is produces in the form of pills of 10 mg, and 20 mg. Tablets should be taken daily at the same time throughout the course of treatment. During treatment, calcium supplements and hepatoprotectors are recommended to use.
The average price of the medication
|Dosage||Quality and Price|
|Nolvadex 10 mg||100 pills — $44|
|Nolvadex 20 mg||100 pills — $60|
Nolvadex generic mechanism of action
Nolvadex has a peripheral effect — it blocks estrogen receptors, thereby preventing the further development of the tumor, but it does not directly affect the level of estrogen in the blood. Therefore, it is used together with a drug that affects the central mechanisms of hormones regulation. Experience in the clinical use of the drug confirms its antitumor activity against hormone-dependent tumors. Medication helps to reduce the level of sex hormones in the blood of men and women, which ensures its therapeutic effect in this pathology. It inhibits the progression of the tumor process, stimulated by estrogen. The effect of estrogen blocking can be observed during couple of weeks after the first dose.
Nolvadex is also effective in the treatment of tumors that are not dependent on the sex hormones level. Its effectiveness is determined by the fact that in tumors of the mammary and prostate glands, receptors for LHCGR through which the direct antitumor effect of Nolvadex is realized. But, unfortunately, it is ineffective in the treatment of patients with metastases (especially in the liver).
What is Nolvadex generic used for?
Currently, the drug is used in the treatment of:
- breast cancer,
- prostate cancer (PC),
- uterine fibroids,
- it is effective in the treatment of patients with dysfunctional uterine bleeding and polycystic ovary syndrome.
In addition, the results of scientific studies have confirmed the effectiveness of Nolvadex in the treatment of ovarian cancer, pancreatic cancer, benign prostatic hyperplasia, etc. This medication can be used to protect ovarian and testicular function during cytostatic chemotherapy. The most promising is the use of Nolvadex in the treatment of inoperable breast cancer in women in the perimenopausal period.
Despite the fact that Nolvadex is very effective in tumor treatment, it’s important to know when this medicine is not recommended. First of all, Nolvadex is forbidden to use during the pregnancy, as it negatively influences on the fetus. The same situation is with breath feeding, the active component of the drug can penetrate into breast milk and cause serious health problems. The allergy and hypersensitivity to any components of the medication; cataract; thrombophlebitis as well as thrombocytopenia.
Also, it’s necessary to underline that the use of the alcohol is not allowed during the Nolvadex treatment. The combination of alcohol and medication reduces the effectiveness of the drug, as well as it could provoke severe cardiovascular issues and cause adverse effects.
The most common Nolvadex side effects
Nolvadex is pretty serious medication that can cause adverse effects more often than other drugs. These side effects may include:
- blood clots;
- hot flashes;
- abdominal pain;
- irregular menstrual periods;
- mood swings;
- liver failure;
- decrease in the number of active spermatozoa;
- vaginal discharge or vaginal bleeding.
Taking Nolvadex can affect the effectiveness of certain medications, just as certain medications can affect how well Nolvadex works. That’s why it is important to consult your doctor before taking the medication. Because there are a number of drugs that can interfere with the effectiveness of Nolvadex.
Sometimes the treatment may be suspended to control adverse reactions such as nausea, vomiting, diarrhea, and anemia, and dose reduction may be considered.